This study addresses the limitations of current ontologies in capturing the dynamic nature of disordered protein regions by pursuing several primary objectives.

New structural and functional ontologies will be developed to accurately represent the structural heterogeneity and dynamic functional annotations of proteins. Collaboration with existing databases and consortia will ensure seamless integration of ontological resources and experimental data, fostering interoperability and accelerating discoveries. Furthermore, a standardized file format specification will be developed in collaboration with the Human Proteome Organization - Proteomics Standards Initiative, facilitating the encoding of structural state transitions within disordered protein regions. 
 

This study involves the participation of multiple ELIXIR Nodes, including ELIXIR Belgium (Wim Vranken), ELIXIR Italy, ELIXIR Hungary, and EMBL-EBI.