DynaMine is a fast predictor of protein backbone dynamics using only sequence information as input. DynaMine is able to accurately distinguish regions of different structural organization within proteins, such as folded domains and disordered linkers of different sizes. Additionally, it can identify disordered regions within proteins with an accuracy comparable to the most sophisticated existing disorder predictors.
DynaMine achieves this high performance without depending on prior disorder knowledge or three-dimensional structural information, which makes it a unique approach in the field as well as providing independent proof of the relationship between dynamics and structural disorder in protein regions.
DynaMine is developed at the Interuniversity Institute of Bioinformatics in Brussels (IB)² and published in Nature Communications (the method) and Nucleic Acids Research (the web-server).