TCRex allows functional interpretation of full human T-cell repertoire data derived from next generation sequencing. The tool is able to link T-cell receptor sequences to a rapidly expanding list of important immunogenic epitopes, consisting of viral and cancer epitopes. TCRex can calculate enrichment statistics and baseline prediction rates to evaluate full repertoires. It also brings together the largest database on TCR-epitope data to train the underlying machine learning models through manual curation of various online resources and scientific literature.
TCRex is developed at the University of Antwerp and has been released for public use in 2018. The manuscript describing the web tool is available in Frontiers of Immunology. Updates on TCRex can be followed on Twitter: @TCRexTool.